Volume 23, Issue 2
Role of Astrocyte in Cortical Spreading Depression: A Quantitative Model of Neuron-Astrocyte Network

Wei Yao, Huaxiong Huang & Robert M. Miura

Commun. Comput. Phys., 23 (2018), pp. 440-458.

Published online: 2018-02

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  • Abstract

Cortical spreading depression (CSD) involves depolarization of neurons and astrocytes due principally to a large increase in extracellular potassium. CSD is also accompanied by large increases in extracellular ATP and is blocked by glutamate Nmethyl-D-aspartate (NMDA) receptor antagonists. In a previous study, we used a neuronal model to investigate the instigation of CSD and propagation of CSD wave by increasing extracellular potassium. In this paper, we extend that model by constructing a neuron-astrocyte network and incorporating the effects of ATP via the coupled biochemical pathways involving glutamate and NMDA currents. We show that both the electrical current stimuli and the local elevation in the extracellular ATP or glutamate concentration can lead to CSD in the coupled neuron-astrocyte model, while ATP or glutamate increase fails to induce CSD when the glutamate NMDA channels are blocked. These results can explain both the potassium theory postulated by Grafstein and glutamate theory by Van Harreveld. Our model showed extracellular potassium plays the key role in CSD instigation and propagation, and glutamate is a key compound mediating CSD by activating NMDA channels through neuron-astrocyte interactive.

  • Keywords

Cortical spreading depression, ion transport, porous media, partial differential equations, finite difference solutions.

  • AMS Subject Headings

35K57, 65M06, 92C05, 92C20

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COPYRIGHT: © Global Science Press

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@Article{CiCP-23-440, author = {}, title = {Role of Astrocyte in Cortical Spreading Depression: A Quantitative Model of Neuron-Astrocyte Network}, journal = {Communications in Computational Physics}, year = {2018}, volume = {23}, number = {2}, pages = {440--458}, abstract = {

Cortical spreading depression (CSD) involves depolarization of neurons and astrocytes due principally to a large increase in extracellular potassium. CSD is also accompanied by large increases in extracellular ATP and is blocked by glutamate Nmethyl-D-aspartate (NMDA) receptor antagonists. In a previous study, we used a neuronal model to investigate the instigation of CSD and propagation of CSD wave by increasing extracellular potassium. In this paper, we extend that model by constructing a neuron-astrocyte network and incorporating the effects of ATP via the coupled biochemical pathways involving glutamate and NMDA currents. We show that both the electrical current stimuli and the local elevation in the extracellular ATP or glutamate concentration can lead to CSD in the coupled neuron-astrocyte model, while ATP or glutamate increase fails to induce CSD when the glutamate NMDA channels are blocked. These results can explain both the potassium theory postulated by Grafstein and glutamate theory by Van Harreveld. Our model showed extracellular potassium plays the key role in CSD instigation and propagation, and glutamate is a key compound mediating CSD by activating NMDA channels through neuron-astrocyte interactive.

}, issn = {1991-7120}, doi = {https://doi.org/10.4208/cicp.OA-2016-0262}, url = {http://global-sci.org/intro/article_detail/cicp/10532.html} }
TY - JOUR T1 - Role of Astrocyte in Cortical Spreading Depression: A Quantitative Model of Neuron-Astrocyte Network JO - Communications in Computational Physics VL - 2 SP - 440 EP - 458 PY - 2018 DA - 2018/02 SN - 23 DO - http://dor.org/10.4208/cicp.OA-2016-0262 UR - https://global-sci.org/intro/cicp/10532.html KW - Cortical spreading depression, ion transport, porous media, partial differential equations, finite difference solutions. AB -

Cortical spreading depression (CSD) involves depolarization of neurons and astrocytes due principally to a large increase in extracellular potassium. CSD is also accompanied by large increases in extracellular ATP and is blocked by glutamate Nmethyl-D-aspartate (NMDA) receptor antagonists. In a previous study, we used a neuronal model to investigate the instigation of CSD and propagation of CSD wave by increasing extracellular potassium. In this paper, we extend that model by constructing a neuron-astrocyte network and incorporating the effects of ATP via the coupled biochemical pathways involving glutamate and NMDA currents. We show that both the electrical current stimuli and the local elevation in the extracellular ATP or glutamate concentration can lead to CSD in the coupled neuron-astrocyte model, while ATP or glutamate increase fails to induce CSD when the glutamate NMDA channels are blocked. These results can explain both the potassium theory postulated by Grafstein and glutamate theory by Van Harreveld. Our model showed extracellular potassium plays the key role in CSD instigation and propagation, and glutamate is a key compound mediating CSD by activating NMDA channels through neuron-astrocyte interactive.

Wei Yao, Huaxiong Huang & Robert M. Miura . (2020). Role of Astrocyte in Cortical Spreading Depression: A Quantitative Model of Neuron-Astrocyte Network. Communications in Computational Physics. 23 (2). 440-458. doi:10.4208/cicp.OA-2016-0262
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