Volume 18, Issue 4
Multiphysics Modeling of Liver Tumor Ablation by High Intensity Focused Ultrasound

Maxim Solovchuk, Tony Wen-Hann Sheu & Marc Thiriet

Commun. Comput. Phys., 18 (2015), pp. 1050-1071.

Published online: 2018-04

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  • Abstract

High intensity focused ultrasound is a rapidly developing technology for the ablation of tumors. Liver cancer is one of the most common malignancies worldwide. Since liver has a large number of blood vessels, blood flow cooling can reduce the necrosed volume and may cause regeneration of the tumor to occur. All cancer cells should be ablated without damaging of the critical tissues. Today, treatment planning tools consider liver as a homogeneous organ. This paper is a step towards the development of surgical planning platform for a non-invasive HIFU tumor ablative therapy in a real liver geometry based on CT/MRI image. This task requires coupling of different physical fields: acoustic, thermal and hydrodynamic. These physical fields can influence each other. In this paper we illustrate how a computational model can be used to improve the treatment efficiency. In large blood vessel both convective cooling and acoustic streaming can change the temperature considerably near blood vessel. The whole tumor ablation took only 30 seconds in the considered simulation case, which is very small comparing with the current treatment time of several hours. Through this study we are convinced that high ultrasound power and nonlinear propagation effects with appropriate treatment planning can sufficiently reduce the treatment time.

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@Article{CiCP-18-1050, author = {}, title = {Multiphysics Modeling of Liver Tumor Ablation by High Intensity Focused Ultrasound}, journal = {Communications in Computational Physics}, year = {2018}, volume = {18}, number = {4}, pages = {1050--1071}, abstract = {

High intensity focused ultrasound is a rapidly developing technology for the ablation of tumors. Liver cancer is one of the most common malignancies worldwide. Since liver has a large number of blood vessels, blood flow cooling can reduce the necrosed volume and may cause regeneration of the tumor to occur. All cancer cells should be ablated without damaging of the critical tissues. Today, treatment planning tools consider liver as a homogeneous organ. This paper is a step towards the development of surgical planning platform for a non-invasive HIFU tumor ablative therapy in a real liver geometry based on CT/MRI image. This task requires coupling of different physical fields: acoustic, thermal and hydrodynamic. These physical fields can influence each other. In this paper we illustrate how a computational model can be used to improve the treatment efficiency. In large blood vessel both convective cooling and acoustic streaming can change the temperature considerably near blood vessel. The whole tumor ablation took only 30 seconds in the considered simulation case, which is very small comparing with the current treatment time of several hours. Through this study we are convinced that high ultrasound power and nonlinear propagation effects with appropriate treatment planning can sufficiently reduce the treatment time.

}, issn = {1991-7120}, doi = {https://doi.org/10.4208/cicp.171214.200715s}, url = {http://global-sci.org/intro/article_detail/cicp/11060.html} }
TY - JOUR T1 - Multiphysics Modeling of Liver Tumor Ablation by High Intensity Focused Ultrasound JO - Communications in Computational Physics VL - 4 SP - 1050 EP - 1071 PY - 2018 DA - 2018/04 SN - 18 DO - http://dor.org/10.4208/cicp.171214.200715s UR - https://global-sci.org/intro/article_detail/cicp/11060.html KW - AB -

High intensity focused ultrasound is a rapidly developing technology for the ablation of tumors. Liver cancer is one of the most common malignancies worldwide. Since liver has a large number of blood vessels, blood flow cooling can reduce the necrosed volume and may cause regeneration of the tumor to occur. All cancer cells should be ablated without damaging of the critical tissues. Today, treatment planning tools consider liver as a homogeneous organ. This paper is a step towards the development of surgical planning platform for a non-invasive HIFU tumor ablative therapy in a real liver geometry based on CT/MRI image. This task requires coupling of different physical fields: acoustic, thermal and hydrodynamic. These physical fields can influence each other. In this paper we illustrate how a computational model can be used to improve the treatment efficiency. In large blood vessel both convective cooling and acoustic streaming can change the temperature considerably near blood vessel. The whole tumor ablation took only 30 seconds in the considered simulation case, which is very small comparing with the current treatment time of several hours. Through this study we are convinced that high ultrasound power and nonlinear propagation effects with appropriate treatment planning can sufficiently reduce the treatment time.

Maxim Solovchuk, Tony Wen-Hann Sheu & Marc Thiriet. (2020). Multiphysics Modeling of Liver Tumor Ablation by High Intensity Focused Ultrasound. Communications in Computational Physics. 18 (4). 1050-1071. doi:10.4208/cicp.171214.200715s
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