Volume 27, Issue 1
Modelling Thermo-Electro-Mechanical Effects in Orthotropic Cardiac Tissue

Ricardo Ruiz-Baier, Alessio Gizzi, Alessandro Loppini, Christian Cherubini & Simonetta Filippi

Commun. Comput. Phys., 27 (2020), pp. 87-115.

Published online: 2019-10

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  • Abstract

In this paper we introduce a new mathematical model for the active contraction of cardiac muscle, featuring different thermo-electric and nonlinear conductivity properties. The passive hyperelastic response of the tissue is described by an orthotropic exponential model, whereas the ionic activity dictates active contraction incorporated through the concept of orthotropic active strain. We use a fully incompressible formulation, and the generated strain modifies directly the conductivity mechanisms in the medium through the pull-back transformation. We also investigate the influence of thermo-electric effects in the onset of multiphysics emergent spatiotemporal dynamics, using nonlinear diffusion. It turns out that these ingredients have a key role in reproducing pathological chaotic dynamics such as ventricular fibrillation during inflammatory events, for instance. The specific structure of the governing equations suggests to cast the problem in mixed-primal form and we write it in terms of Kirchhoff stress, displacements, solid pressure, dimensionless electric potential, activation generation, and ionic variables. We also advance a new mixed-primal finite element method for its numerical approximation, and we use it to explore the properties of the model and to assess the importance of coupling terms, by means of a few computational experiments in 3D.

  • Keywords

Cardiac electromechanics, orthotropic active strain, thermo-electric coupling, scroll wave propagation, numerical simulations.

  • AMS Subject Headings

92C10, 74S05, 65M60, 74F25

  • Copyright

COPYRIGHT: © Global Science Press

  • Email address

ruizbaier@maths.ox.ac.uk (Ricardo Ruiz-Baier)

a.gizzi@unicampus.it (Alessio Gizzi)

a.loppini@unicampus.it (Alessandro Loppini)

c.cherubini@unicampus.it (Christian Cherubini)

s.filippi@unicampus.it (Simonetta Filippi)

  • BibTex
  • RIS
  • TXT
@Article{CiCP-27-87, author = {Ruiz-Baier , Ricardo and Gizzi , Alessio and Loppini , Alessandro and Cherubini , Christian and Filippi , Simonetta }, title = {Modelling Thermo-Electro-Mechanical Effects in Orthotropic Cardiac Tissue}, journal = {Communications in Computational Physics}, year = {2019}, volume = {27}, number = {1}, pages = {87--115}, abstract = {

In this paper we introduce a new mathematical model for the active contraction of cardiac muscle, featuring different thermo-electric and nonlinear conductivity properties. The passive hyperelastic response of the tissue is described by an orthotropic exponential model, whereas the ionic activity dictates active contraction incorporated through the concept of orthotropic active strain. We use a fully incompressible formulation, and the generated strain modifies directly the conductivity mechanisms in the medium through the pull-back transformation. We also investigate the influence of thermo-electric effects in the onset of multiphysics emergent spatiotemporal dynamics, using nonlinear diffusion. It turns out that these ingredients have a key role in reproducing pathological chaotic dynamics such as ventricular fibrillation during inflammatory events, for instance. The specific structure of the governing equations suggests to cast the problem in mixed-primal form and we write it in terms of Kirchhoff stress, displacements, solid pressure, dimensionless electric potential, activation generation, and ionic variables. We also advance a new mixed-primal finite element method for its numerical approximation, and we use it to explore the properties of the model and to assess the importance of coupling terms, by means of a few computational experiments in 3D.

}, issn = {1991-7120}, doi = {https://doi.org/10.4208/cicp.OA-2018-0253}, url = {http://global-sci.org/intro/article_detail/cicp/13315.html} }
TY - JOUR T1 - Modelling Thermo-Electro-Mechanical Effects in Orthotropic Cardiac Tissue AU - Ruiz-Baier , Ricardo AU - Gizzi , Alessio AU - Loppini , Alessandro AU - Cherubini , Christian AU - Filippi , Simonetta JO - Communications in Computational Physics VL - 1 SP - 87 EP - 115 PY - 2019 DA - 2019/10 SN - 27 DO - http://doi.org/10.4208/cicp.OA-2018-0253 UR - https://global-sci.org/intro/article_detail/cicp/13315.html KW - Cardiac electromechanics, orthotropic active strain, thermo-electric coupling, scroll wave propagation, numerical simulations. AB -

In this paper we introduce a new mathematical model for the active contraction of cardiac muscle, featuring different thermo-electric and nonlinear conductivity properties. The passive hyperelastic response of the tissue is described by an orthotropic exponential model, whereas the ionic activity dictates active contraction incorporated through the concept of orthotropic active strain. We use a fully incompressible formulation, and the generated strain modifies directly the conductivity mechanisms in the medium through the pull-back transformation. We also investigate the influence of thermo-electric effects in the onset of multiphysics emergent spatiotemporal dynamics, using nonlinear diffusion. It turns out that these ingredients have a key role in reproducing pathological chaotic dynamics such as ventricular fibrillation during inflammatory events, for instance. The specific structure of the governing equations suggests to cast the problem in mixed-primal form and we write it in terms of Kirchhoff stress, displacements, solid pressure, dimensionless electric potential, activation generation, and ionic variables. We also advance a new mixed-primal finite element method for its numerical approximation, and we use it to explore the properties of the model and to assess the importance of coupling terms, by means of a few computational experiments in 3D.

Ricardo Ruiz-Baier, Alessio Gizzi, Alessandro Loppini, Christian Cherubini & Simonetta Filippi. (2019). Modelling Thermo-Electro-Mechanical Effects in Orthotropic Cardiac Tissue. Communications in Computational Physics. 27 (1). 87-115. doi:10.4208/cicp.OA-2018-0253
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