Volume 1, Issue 6
Inverse Eigenvalue Problems for Exploring the Dynamics of Systems Biology Models

James Lu

10.4208/aamm.09-m09S04

Adv. Appl. Math. Mech., 1 (2009), pp. 711-728.

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  • Abstract

This paper describes inverse eigenvalue problems that arise in studying qualitative dynamics in systems biology models. An algorithm based on lift-and-project iterations is proposed, where the lifting step entails solving a constrained matrix inverse eigenvalue problem. In particular, prior to carrying out the iterative steps, \textit{a-priori} bounds on the entries of the Jacobian matrix are computed by relying on the reaction network structure as well as the form of the rate law expressions for the model under consideration. Numerical results on a number of models show that the proposed algorithm can be used to computationally explore the possible dynamical scenarios while identifying the important mechanisms via the use of sparsity-promoting regularization.

  • History

Published online: 2009-01

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